PDE6C

Across TCGA patient cohorts, PDE6C mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6C-associated genes across cancer lineages are eIF4E, Src, and 4E-BP1_pS65. Each is linked with PDE6C in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6C-to-partner and partner-to-PDE6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PDE6C-low versus PDE6C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6C→partner) and Y-score (partner→PDE6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+3.087	.005	<.001	3	2
SKCM	Src →	-0.202	-1.983	.014	.027	3	2
SKCM	4E-BP1_pS65 →	+0.149	+3.169	.036	.017	3	2
SKCM	CDK1_pY15 →	+0.264	+3.199	.018	.007	3	2
UCEC	ATM →	-0.593	-3.000	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.324	+2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by PDE6C expression — UCEC

Explore this box plot interactively →