PDE6C

Across TCGA cell cohorts, PDE6C RNA expression is significantly associated with the go_rna of many other GO terms, with 2,275 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE6C-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Negative regulation of telomere maintenance, and Pre-mRNA catabolic process. Each is linked with PDE6C in more than 11 cancer types. Because this analysis shows association rather than direction, both PDE6C-to-partner and partner-to-PDE6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by PDE6C-low versus PDE6C-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6C→partner) and Y-score (partner→PDE6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.217	+0.139	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of telomere maintenance →	+0.091	+0.168	<.001	.003	3	11
BONE	Pre-mRNA catabolic process →	+0.223	+0.133	<.001	.005	2	12
BONE	Viral transcription →	+0.119	+0.147	<.001	<.001	3	11
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.124	-0.108	<.001	.001	3	10
BONE	Subtelomeric heterochromatin formation →	+0.113	+0.088	.004	.008	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,275 associations by consensus.

Calcium-independent cell-matrix adhesion by PDE6C expression — BONE

Explore this box plot interactively →