PDE6C

Across TCGA cell cohorts, PDE6C mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE6C-associated genes across cancer lineages are LRRC74A, KRTAP1-1, and OR10G3. Each is linked with PDE6C in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6C-to-partner and partner-to-PDE6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC74A grouped by PDE6C-low versus PDE6C-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6C→partner) and Y-score (partner→PDE6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LRRC74A →	+0.110	+4.269	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	1
SKIN	OR10G3 →	+0.002	+3.700	<.001	.009	3	1
SKIN	TEX26 →	+0.076	+4.047	<.001	<.001	3	1
SKIN	TPPP2 →	+0.043	+3.217	<.001	.006	3	1
SKIN	H4C13 →	+0.210	+3.518	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

LRRC74A by PDE6C expression — LUNG_SCLC

Explore this box plot interactively →