PDE6B

Across TCGA patient cohorts, PDE6B RNA expression is significantly associated with the protein abundance of many other proteins, with 12,243 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PDE6B-associated proteins across cancer lineages are RPS2, EEF2, and RPL5. Each is linked with PDE6B in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE6B versus RPS2 in HNSC, with a Pearson correlation of -0.25.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS2 →	-0.206	-0.510	<.001	<.001	3	5
BRCA	EEF2 →	-0.248	-0.951	<.001	<.001	3	5
GBM	RPL5 →	-0.196	-0.651	<.001	<.001	3	4
GBM	RPL7 →	-0.369	-0.533	<.001	.003	3	4
COAD	SCRN1 →	+0.353	+0.279	.001	<.001	3	4
UCEC	ADA2 →	+0.514	+0.592	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,243 associations by consensus.

PDE6B vs RPS2 — HNSC

Explore this scatter interactively →