PDE6B

Across TCGA patient cohorts, PDE6B protein abundance is significantly associated with the RNA expression of many other genes, with 11,340 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE6B-associated genes across cancer lineages are FAS, ATP8B4, and GIMAP6. Each is linked with PDE6B in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE6B versus FAS in BRCA, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAS →	-0.669	-0.339	<.001	<.001	3	7
UCEC	ATP8B4 →	-0.580	-0.303	<.001	<.001	3	6
BRCA	GIMAP6 →	-0.906	-0.392	<.001	<.001	3	6
BRCA	GLIPR1 →	-0.774	-0.410	<.001	<.001	3	6
COAD	IGSF6 →	-0.941	-0.299	<.001	.001	3	6
UCEC	EMP3 →	-0.834	-0.393	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,340 associations by consensus.

PDE6B vs FAS — BRCA

Explore this scatter interactively →