PDE6B

Across TCGA patient cohorts, PDE6B mutation is significantly associated with the RNA expression of many other genes, with 3,141 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6B-associated genes across cancer lineages are SLBP, RPL22P20, and MTA2. Each is linked with PDE6B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLBP grouped by PDE6B-low versus PDE6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLBP →	+0.486	+1.698	<.001	<.001	3	3
LGG	RPL22P20 →	+0.125	+4.131	.004	.004	3	3
UCEC	MTA2 →	+0.320	+1.752	.001	<.001	3	3
UCEC	CENPU →	+0.471	+2.247	.005	.001	3	3
UCEC	HAUS1 →	+0.457	+3.828	.001	<.001	3	3
UCEC	PKN3 →	+0.601	+2.769	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,141 associations by consensus.

SLBP by PDE6B expression — UCEC

Explore this box plot interactively →