PDE6B

Across TCGA patient cohorts, PDE6B mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6B-associated genes across cancer lineages are MIG-6, TFRC, and Cyclin-B1. Each is linked with PDE6B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by PDE6B-low versus PDE6B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.093	+2.229	.045	.032	3	3
UCEC	TFRC →	+0.554	+1.523	.001	.008	3	3
UCEC	Cyclin-B1 →	+0.503	+3.700	.005	.001	3	3
STAD	Caspase-7-cleavedD198 →	+0.759	+3.000	.048	.036	2	3
COAD	FASN →	+0.373	+2.178	.042	.035	3	2
SKCM	PI3K-p85 →	+0.185	+2.128	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MIG-6 by PDE6B expression — COAD

Explore this box plot interactively →