PDE6B

Across TCGA cell cohorts, PDE6B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,522 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDE6B-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Aerobic electron transport chain, and Cytoplasmic translation. Each is linked with PDE6B in more than 10 cancer types. Because this analysis shows association rather than direction, both PDE6B-to-partner and partner-to-PDE6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PDE6B-low versus PDE6B-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6B→partner) and Y-score (partner→PDE6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.108	+1.947	<.001	<.001	3	11
OVARY	Aerobic electron transport chain →	+0.085	+1.713	<.001	<.001	3	11
OVARY	Cytoplasmic translation →	+0.073	+1.791	<.001	<.001	3	11
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.098	+1.947	<.001	<.001	3	11
BONE	Proton motive force-driven mitochondrial ATP synthesis →	+0.087	+1.930	.007	.003	3	11
OVARY	Oxidative phosphorylation →	+0.084	+1.713	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,522 associations by consensus.

Negative regulation of myoblast fusion by PDE6B expression — OVARY

Explore this box plot interactively →