PDE5A

Across TCGA patient cohorts, PDE5A RNA expression is significantly associated with the protein abundance of many other proteins, with 16,896 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDE5A-associated proteins across cancer lineages are KANK2, ARHGEF17, and PRKG1. Each is linked with PDE5A in more than 7 cancer types. Because this analysis shows association rather than direction, both PDE5A-to-partner and partner-to-PDE5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE5A versus KANK2 in CCRCC, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE5A→partner) and Y-score (partner→PDE5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KANK2 →	+0.564	+0.651	<.001	<.001	3	8
CCRCC	ARHGEF17 →	+0.426	+0.601	<.001	<.001	3	7
CCRCC	PRKG1 →	+0.730	+0.833	<.001	<.001	3	7
UCEC	RSU1 →	+0.435	+0.590	.005	.003	3	7
HNSC	C11orf96 →	+0.639	+0.765	<.001	<.001	3	7
BRCA	CAVIN1 →	+0.715	+0.816	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,896 associations by consensus.

PDE5A vs KANK2 — CCRCC

Explore this scatter interactively →