PDE5A

Across TCGA patient cohorts, PDE5A protein abundance is significantly associated with the RNA expression of many other genes, with 16,808 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PDE5A-associated genes across cancer lineages are PCDH18, PGM5, and EMCN. Each is linked with PDE5A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE5A-to-partner and partner-to-PDE5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE5A versus PCDH18 in CCRCC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE5A→partner) and Y-score (partner→PDE5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PCDH18 →	+0.996	+0.341	<.001	<.001	3	7
UCEC	PGM5 →	+1.060	+0.384	<.001	<.001	3	7
UCEC	EMCN →	+0.987	+0.357	<.001	<.001	3	7
UCEC	MAMDC2 →	+1.101	+0.381	<.001	<.001	3	6
BRCA	NXPH3 →	+0.965	+0.507	.002	.001	3	6
CCRCC	LHFPL6 →	+1.107	+0.394	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,808 associations by consensus.

PDE5A vs PCDH18 — CCRCC

Explore this scatter interactively →