PDE5A

Across TCGA patient cohorts, PDE5A mutation is significantly associated with the RNA expression of many other genes, with 4,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE5A-associated genes across cancer lineages are COX6CP16, MCUB, and ITGAE. Each is linked with PDE5A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE5A-to-partner and partner-to-PDE5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP16 grouped by PDE5A-low versus PDE5A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE5A→partner) and Y-score (partner→PDE5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COX6CP16 →	+0.528	+3.516	<.001	.004	3	3
UCEC	MCUB →	+0.559	+1.794	<.001	<.001	3	3
BLCA	ITGAE →	+0.766	+3.191	<.001	.009	3	3
UCEC	BCAM →	-0.939	-3.247	<.001	<.001	3	3
BLCA	NDUFA8P1 →	+0.096	+2.878	.001	.003	3	3
UCEC	IGFBP4 →	-0.580	-1.762	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,185 associations by consensus.

COX6CP16 by PDE5A expression — COAD

Explore this box plot interactively →