PDE5A

Across TCGA patient cohorts, PDE5A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE5A-associated genes across cancer lineages are ASNS, ATM, and 4E-BP1_pT37_T46. Each is linked with PDE5A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE5A-to-partner and partner-to-PDE5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PDE5A-low versus PDE5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE5A→partner) and Y-score (partner→PDE5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.309	+1.222	.003	.032	3	3
UCEC	ATM →	-0.521	-3.156	<.001	<.001	3	3
BLCA	4E-BP1_pT37_T46 →	-0.463	-3.000	.043	.036	3	2
UCEC	EGFR_pY1068 →	-0.287	-1.857	<.001	<.001	3	2
UCEC	eIF4E →	+0.178	+2.321	.004	<.001	3	2
UCEC	JNK2 →	+0.200	+2.026	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ASNS by PDE5A expression — UCEC

Explore this box plot interactively →