PDE4DIP

Across TCGA patient cohorts, PDE4DIP protein abundance is significantly associated with the RNA expression of many other genes, with 13,543 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE4DIP-associated genes across cancer lineages are CADPS2, XBP1, and SULT2B1. Each is linked with PDE4DIP in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE4DIP-to-partner and partner-to-PDE4DIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE4DIP versus CADPS2 in LSCC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4DIP→partner) and Y-score (partner→PDE4DIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CADPS2 →	+0.999	+0.295	<.001	<.001	3	5
UCEC	XBP1 →	+0.833	+0.174	.007	.009	3	4
HNSC	SULT2B1 →	-1.243	-0.210	<.001	<.001	3	4
UCEC	PON2 →	+0.759	+0.247	<.001	.001	3	4
UCEC	IFT22 →	+0.557	+0.179	.006	.008	3	4
LSCC	CDH13 →	-1.515	-0.338	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,543 associations by consensus.

PDE4DIP vs CADPS2 — LSCC

Explore this scatter interactively →