PDE4DIP

Across TCGA cell cohorts, PDE4DIP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,211 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PDE4DIP-associated GO terms across cancer lineages are Positive regulation of microtubule nucleation, Astral microtubule organization, and Regulation of microtubule nucleation. Each is linked with PDE4DIP in more than 17 cancer types. Because this analysis shows association rather than direction, both PDE4DIP-to-partner and partner-to-PDE4DIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of microtubule nucleation grouped by PDE4DIP-low versus PDE4DIP-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4DIP→partner) and Y-score (partner→PDE4DIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of microtubule nucleation →	+0.158	+1.415	.002	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Astral microtubule organization →	+0.148	+1.105	<.001	<.001	3	16
BLOOD_Myeloma	Regulation of microtubule nucleation →	+0.132	+1.478	<.001	<.001	3	14
OESOPHAGUS	Endosomal transport →	+0.088	+1.475	<.001	.001	3	13
OESOPHAGUS	Positive regulation of microtubule polymerization →	+0.101	+1.218	.009	.001	3	13
STOMACH	Golgi vesicle transport →	+0.077	+1.554	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,211 associations by consensus.

Positive regulation of microtubule nucleation by PDE4DIP expression — LIVER

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