PDE4DIP

Across TCGA cell cohorts, PDE4DIP mutation is significantly associated with the RNA expression of many other genes, with 2,225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE4DIP-associated genes across cancer lineages are PKN3, REC114, and EIF3D. Each is linked with PDE4DIP in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE4DIP-to-partner and partner-to-PDE4DIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by PDE4DIP-low versus PDE4DIP-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4DIP→partner) and Y-score (partner→PDE4DIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PKN3 →	+1.176	+1.944	.003	.008	3	3
UPPER_AERODIGESTIVE_TRACT	REC114 →	+0.042	+2.862	.004	.007	3	3
LARGE_INTESTINE	EIF3D →	+0.317	+1.545	.008	.004	3	3
LARGE_INTESTINE	RNMT →	+0.630	+2.463	<.001	<.001	3	3
LARGE_INTESTINE	TBCCD1 →	+0.513	+3.700	<.001	<.001	3	3
LARGE_INTESTINE	SSX2IP →	+1.056	+2.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,225 associations by consensus.

PKN3 by PDE4DIP expression — STOMACH

Explore this box plot interactively →