PDE4D

Across TCGA pan-cancer cohorts, PDE4D Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDE4D data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PDE4D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE4D expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

ESCA, DLBC, and COAD are the cancer types where PDE4D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.051	0.536	<.001	18	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
COAD	OS	Median	IV	0.056	0.649	<.001	12	view →
UCS	DFS	Median	All	0.132	0.530	.041	6	view →
SARC	OS	Median	All	0.174	0.745	.005	6	view →
UCEC	DFS	Median	II,III,IV	0.861	0.429	.022	6	view →
HNSC	DFS	Median	All	1.000	0.319	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDE4D–ESCA (DFS)

Open the ESCA breakdown →