PDE4D

Across TCGA pan-cancer cohorts, PDE4D mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDE4D data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDE4D mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDE4D expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where PDE4D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.932	0.992	.019	13	view →
CCRCC	DFS	Quartile	All	0.562	0.853	.021	9	view →
LUAD	OS	Tertile	II,III,IV	0.260	0.749	.002	9	view →
UCEC	OS	Median	All	0.968	0.849	.022	4	view →
PDAC	OS	Tertile	II,III,IV	0.759	0.882	.021	4	view →
LSCC	DFS	Median	All	0.914	0.962	.025	3	view →
GBM	OS	Median	All	0.657	0.418	.005	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDE4D–HNSC (OS)

Open the HNSC breakdown →