PDE4D

Across TCGA patient cohorts, PDE4D RNA expression is significantly associated with the protein abundance of many other proteins, with 12,699 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDE4D-associated proteins across cancer lineages are PDE4D_S754, C1orf122, and HSPH1. Each is linked with PDE4D in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE4D versus PDE4D_S754 in LUAD, with a Pearson correlation of 0.80.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDE4D_S754 →	+1.243	+1.427	<.001	<.001	3	7
LSCC	C1orf122 →	-0.248	-0.492	<.001	.001	3	4
COAD	HSPH1 →	-0.505	-0.509	<.001	<.001	3	4
HNSC	MAP7D1_S313 →	-0.530	-0.514	<.001	<.001	3	4
BRCA	TBRG4 →	-0.408	-0.608	<.001	<.001	3	4
UCEC	AIDA →	+0.290	+1.055	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,699 associations by consensus.

PDE4D vs PDE4D_S754 — LUAD

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