PDE4D

Across TCGA patient cohorts, PDE4D protein abundance is significantly associated with the RNA expression of many other genes, with 11,128 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDE4D-associated genes across cancer lineages are NDUFB4P2, FGF7, and C7. Each is linked with PDE4D in more than 5 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE4D versus NDUFB4P2 in LUAD, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDUFB4P2 →	+1.718	+0.870	<.001	<.001	3	6
COAD	FGF7 →	+1.077	+0.422	<.001	<.001	3	5
UCEC	C7 →	+1.696	+0.508	<.001	<.001	3	4
GBM	PDE1A →	+1.152	+0.516	<.001	<.001	3	4
GBM	NECAB1 →	+0.898	+0.360	<.001	<.001	3	4
HNSC	LYVE1 →	+1.423	+0.344	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,128 associations by consensus.

PDE4D vs NDUFB4P2 — LUAD

Explore this scatter interactively →