PDE4D

Across TCGA patient cohorts, PDE4D mutation is significantly associated with the RNA expression of many other genes, with 5,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4D-associated genes across cancer lineages are PIK3AP1, KLRD1, and RNY4P20. Each is linked with PDE4D in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIK3AP1 grouped by PDE4D-low versus PDE4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIK3AP1 →	+0.519	+1.376	.002	.001	3	3
UCEC	KLRD1 →	+0.292	+2.085	<.001	<.001	3	3
LGG	RNY4P20 →	+0.291	+4.778	<.001	.004	3	2
CESC	RNU1-7P →	+0.115	+4.757	<.001	.004	3	2
CESC	TRDJ3 →	+0.990	+3.855	.001	.008	3	2
SKCM	DIMT1P1 →	+0.017	+3.897	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,191 associations by consensus.

PIK3AP1 by PDE4D expression — UCEC

Explore this box plot interactively →