PDE4D

Across TCGA cell cohorts, PDE4D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,612 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDE4D-associated GO terms across cancer lineages are Regulation of cell communication by electrical coupling involved in cardiac conduction, Regulation of relaxation of cardiac muscle, and CAMP metabolic process. Each is linked with PDE4D in more than 12 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell communication by electrical coupling involved in cardiac conduction grouped by PDE4D-low versus PDE4D-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of cell communication by electrical coupling involved in cardiac conduction →	-0.159	-1.554	<.001	<.001	3	13
PANCREAS	Regulation of relaxation of cardiac muscle →	+1.491	+1.543	<.001	<.001	3	10
LUNG_SCLC	CAMP metabolic process →	+0.117	+1.303	.002	.008	3	10
BONE	Regulation of cell communication by electrical coupling →	-0.153	-1.135	.001	.004	3	10
SOFT_TISSUE	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel →	+0.122	+2.033	<.001	<.001	3	9
LIVER	Oxidative phosphorylation →	+0.104	+2.314	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,612 associations by consensus.

Regulation of cell communication by electrical coupling involved in cardiac conduction by PDE4D expression — LARGE_INTESTINE

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