PDE4D

Across TCGA cell cohorts, PDE4D mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE4D-associated genes across cancer lineages are PF4V1, H2BC1, and H2AC1. Each is linked with PDE4D in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE4D-to-partner and partner-to-PDE4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF4V1 grouped by PDE4D-low versus PDE4D-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4D→partner) and Y-score (partner→PDE4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PF4V1 →	+0.626	+3.832	<.001	.005	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PF4V1 by PDE4D expression — CNS

Explore this box plot interactively →