PDE3A

Across TCGA cell cohorts, PDE3A mutation is significantly associated with the RNA expression of many other genes, with 1,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE3A-associated genes across cancer lineages are ADAM7, F11, and WFDC10A. Each is linked with PDE3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE3A-to-partner and partner-to-PDE3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by PDE3A-low versus PDE3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3A→partner) and Y-score (partner→PDE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.002	+2.208	<.001	.002	3	3
LARGE_INTESTINE	F11 →	+0.028	+2.145	.001	.001	3	3
LUNG_SCLC	WFDC10A →	+0.741	+3.232	<.001	.008	3	2
LUNG_SCLC	BOD1L2 →	+0.005	+3.070	.001	.009	3	2
BLOOD_Leukemia	LRIT1 →	+0.046	+5.269	<.001	<.001	3	2
BLOOD_Leukemia	OR1L3 →	+0.085	+4.276	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,558 associations by consensus.

ADAM7 by PDE3A expression — LARGE_INTESTINE

Explore this box plot interactively →