Across TCGA patient cohorts, PDE2A RNA expression is significantly associated with the protein abundance of many other proteins, with 26,705 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDE2A-associated proteins across cancer lineages are CAVIN2, LDB3, and TMOD1. Each is linked with PDE2A in more than 8 cancer types. Because this analysis shows association rather than direction, both PDE2A-to-partner and partner-to-PDE2A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE2A→partner) and Y-score (partner→PDE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN2 →	+0.782	+0.659	<.001	<.001	3	9
HNSC	LDB3 →	+1.103	+0.509	<.001	.002	3	9
HNSC	TMOD1 →	+1.210	+0.916	<.001	<.001	3	8
GBM	TMOD2 →	+0.546	+1.248	<.001	<.001	3	8
UCEC	PPP1R12B →	+1.044	+0.654	<.001	.003	3	8
COAD	PPP1R12C →	+0.441	+0.499	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,705 associations by consensus.

Exploration

PDE2A survival (RNA) · tumor vs normal (RNA) · all PDE2A data types