Across TCGA patient cohorts, PDE2A mutation is significantly associated with the RNA expression of many other genes, with 2,864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE2A-associated genes across cancer lineages are OXA1L, GCAT, and MRPL37. Each is linked with PDE2A in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE2A-to-partner and partner-to-PDE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE2A→partner) and Y-score (partner→PDE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OXA1L →	+0.355	+2.106	.002	.003	3	4
UCEC	GCAT →	+0.447	+3.983	.005	<.001	3	4
UCEC	MRPL37 →	+0.387	+2.050	.001	<.001	3	4
UCEC	PARP2 →	+0.429	+1.807	<.001	<.001	3	4
SKCM	LDHA →	+0.658	+2.845	<.001	.001	3	4
UCEC	STX5 →	+0.292	+2.408	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,864 associations by consensus.

Exploration

PDE2A survival (RNA) · tumor vs normal (RNA) · all PDE2A data types