Across TCGA patient cohorts, PDE2A mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE2A-associated genes across cancer lineages are STAT3_pY705, Cyclin-E2, and MEK1. Each is linked with PDE2A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE2A-to-partner and partner-to-PDE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE2A→partner) and Y-score (partner→PDE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.328	-1.584	<.001	.015	3	3
COAD	Cyclin-E2 →	+0.267	+3.195	.014	.009	3	3
UCEC	MEK1 →	+0.353	+2.263	.003	<.001	3	2
UCEC	JNK2 →	+0.273	+2.643	<.001	<.001	3	2
UCEC	p27_pT157 →	-0.040	-1.652	.037	.006	3	2
COAD	PCNA →	+0.390	+2.178	<.001	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

PDE2A survival (RNA) · tumor vs normal (RNA) · all PDE2A data types