Across TCGA cell cohorts, PDE2A mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE2A-associated genes across cancer lineages are DEFB108B, TEX13A, and UNC93A. Each is linked with PDE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE2A-to-partner and partner-to-PDE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE2A→partner) and Y-score (partner→PDE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	2
LUNG_NSCLC_LUAD	TEX13A →	+0.008	+3.189	.004	.007	3	2
BLOOD_Leukemia	UNC93A →	+0.154	+3.944	<.001	.006	3	1
BLOOD_Leukemia	VSX2 →	+0.026	+4.258	.002	.002	3	1
BLOOD_Leukemia	C20orf85 →	+0.041	+5.554	<.001	<.001	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

Exploration

PDE2A survival (RNA) · tumor vs normal (RNA) · all PDE2A data types