PDE2A-AS2

Across TCGA pan-cancer cohorts, PDE2A-AS2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PDE2A-AS2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PDE2A-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDE2A-AS2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

UVM, ACC, and LAML are the cancer types where PDE2A-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.388	0.841	<.001	128	view →
ACC	OS	Tertile	All	0.362	0.793	<.001	84	view →
LAML	DFS	Median	All	0.405	0.714	<.001	48	view →
LUAD	OS	Tertile	II,III,IV	0.871	0.653	.002	45	view →
THYM	DFS	Quartile	All	0.824	1.000	.006	43	view →
STAD	OS	Quartile	All	0.502	0.729	<.001	40	view →
KIRC	DFS	Median	IV	0.203	0.453	.001	37	view →
COAD	DFS	Median	II,III,IV	0.337	0.737	.001	36	view →
DLBC	DFS	Median	II,III,IV	0.511	0.895	.007	29	view →
KIRP	OS	Median	III,IV	0.312	0.613	.010	27	view →
MESO	OS	Median	II,III,IV	0.291	0.755	.001	24	view →
LIHC	DFS	Median	All	0.625	0.477	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PDE2A-AS2–UVM (OS)

Open the UVM breakdown →