PDE2A-AS2

Across TCGA pan-cancer cohorts, PDE2A-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PDE2A-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDE2A-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDE2A-AS2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where PDE2A-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE2A-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.849	<.001	12	view →
KIRC	All	IV	+0.544	<.001	12	view →
BRCA	All	III,IV	+0.414	<.001	6	view →
COAD	Female	IV	−0.825	.015	4	view →
KICH	All	All	−0.355	.003	3	view →
LUAD	All	III,IV	−0.323	.024	3	view →
ESCA	All	II,III,IV	+1.089	.022	2	view →
LIHC	Male	All	−0.211	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PDE2A-AS2–HNSC

Open the HNSC breakdown →