PDE2A-AS1

Across TCGA pan-cancer cohorts, PDE2A-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PDE2A-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PDE2A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and SKCM show a favorable association.

UCS, UCEC, and ACC are the cancer types where PDE2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	IV	0.132	0.718	.002	108	view →
UCEC	DFS	Tertile	All	0.285	0.661	<.001	90	view →
ACC	OS	Tertile	All	0.133	0.686	.004	57	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	45	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	45	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
GBM	OS	Tertile	All	0.237	0.448	<.001	36	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	36	view →
HNSC	DFS	Tertile	II,III,IV	0.567	0.705	.028	21	view →
KIRP	OS	Tertile	All	0.818	0.953	.014	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	12	view →
LAML	DFS	Quartile	All	0.152	0.475	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PDE2A-AS1–UCS (DFS)

Open the UCS breakdown →