PDE2A-AS1

Across TCGA pan-cancer cohorts, PDE2A-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PDE2A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PDE2A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDE2A-AS1 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KICH, LUSC, and COAD are the cancer types where PDE2A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE2A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	+0.132	.005	5	view →
LUSC	All	All	−0.041	.026	3	view →
COAD	All	All	−0.019	.011	3	view →
LUAD	Male	All	−0.096	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PDE2A-AS1–KICH

Open the KICH breakdown →