PDE1C

Across TCGA pan-cancer cohorts, PDE1C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDE1C data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PDE1C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDE1C expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where PDE1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.842	1.000	.020	5	view →
LSCC	OS	Tertile	All	1.000	0.669	.031	5	view →
CCRCC	DFS	Quartile	All	1.000	0.498	.049	2	view →
UCEC	OS	Median	All	0.968	0.825	.049	2	view →
PDAC	DFS	Quartile	II,III,IV	0.318	0.607	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDE1C–LUAD (OS)

Open the LUAD breakdown →