PDE1B

Across TCGA patient cohorts, PDE1B protein abundance is significantly associated with the RNA expression of many other genes, with 9,000 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDE1B-associated genes across cancer lineages are CNRIP1, HSPA12B, and TCEAL7. Each is linked with PDE1B in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE1B-to-partner and partner-to-PDE1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE1B versus CNRIP1 in OV, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1B→partner) and Y-score (partner→PDE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	+1.170	+1.704	<.001	<.001	3	5
CCRCC	HSPA12B →	+1.316	+0.539	<.001	<.001	3	5
UCEC	TCEAL7 →	+1.389	+0.963	<.001	<.001	3	5
OV	LHFPL6 →	+1.228	+1.213	.002	.004	3	5
OV	DACT3 →	+1.116	+2.040	.003	.002	3	5
UCEC	LMOD1 →	+1.508	+0.587	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,000 associations by consensus.

PDE1B vs CNRIP1 — OV

Explore this scatter interactively →