PDE1B

Across TCGA patient cohorts, PDE1B mutation is significantly associated with the RNA expression of many other genes, with 1,853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE1B-associated genes across cancer lineages are AATF, TERF2IP, and DAPK3. Each is linked with PDE1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE1B-to-partner and partner-to-PDE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AATF grouped by PDE1B-low versus PDE1B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1B→partner) and Y-score (partner→PDE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AATF →	+0.299	+2.106	.006	.003	3	3
UCEC	TERF2IP →	+0.415	+2.169	.006	.003	3	3
UCEC	DAPK3 →	+0.375	+3.708	.009	<.001	3	3
UCEC	STX8 →	+0.393	+2.246	.002	.005	3	3
UCEC	SZRD1 →	+0.296	+3.343	.007	.005	3	3
UCEC	CAPZB →	+0.383	+3.354	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,853 associations by consensus.

AATF by PDE1B expression — SKCM

Explore this box plot interactively →