PDE1B

Across TCGA cell cohorts, PDE1B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,059 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDE1B-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Oxidative phosphorylation. Each is linked with PDE1B in more than 10 cancer types. Because this analysis shows association rather than direction, both PDE1B-to-partner and partner-to-PDE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PDE1B-low versus PDE1B-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1B→partner) and Y-score (partner→PDE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.087	+0.293	<.001	.002	3	11
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.087	+0.127	.002	.009	2	11
BONE	Oxidative phosphorylation →	+0.076	+2.808	.002	<.001	3	10
BREAST	Regulation of myoblast fusion →	+0.072	+0.095	<.001	.004	3	9
BREAST	Spliceosomal complex assembly →	+0.067	+0.122	<.001	.002	3	9
BONE	Regulation of DNA repair →	+0.065	+2.371	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,059 associations by consensus.

Negative regulation of myoblast fusion by PDE1B expression — OVARY

Explore this box plot interactively →