PDE1A

Across TCGA patient cohorts, PDE1A protein abundance is significantly associated with the RNA expression of many other genes, with 14,742 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDE1A-associated genes across cancer lineages are ZCCHC24, SEMA3G, and SEPTIN4. Each is linked with PDE1A in more than 4 cancer types. Because this analysis shows association rather than direction, both PDE1A-to-partner and partner-to-PDE1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE1A versus ZCCHC24 in OV, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1A→partner) and Y-score (partner→PDE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZCCHC24 →	+1.056	+0.672	<.001	.003	3	5
CCRCC	SEMA3G →	+1.088	+0.293	<.001	<.001	3	4
GBM	SEPTIN4 →	+1.046	+0.790	<.001	<.001	3	4
UCEC	CNRIP1 →	+1.193	+0.781	.004	<.001	3	4
OV	TMEM88 →	+0.870	+0.834	<.001	.005	3	4
PDAC	ADH1B →	+1.602	+0.484	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,742 associations by consensus.

PDE1A vs ZCCHC24 — OV

Explore this scatter interactively →