PDE1A

Across TCGA pan-cancer cohorts, PDE1A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PDE1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PDE1A RNA is repressed in tumor relative to normal tissue. In most cancer types PDE1A is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where PDE1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.419	<.001	12	view →
BLCA	Male	III,IV	−2.718	<.001	11	view →
KICH	Male	II,III,IV	−1.953	<.001	10	view →
COAD	All	II,III,IV	−0.711	<.001	9	view →
UCEC	All	III,IV	−2.255	<.001	8	view →
KIRP	Male	All	−3.162	<.001	7	view →
BRCA	All	II,III,IV	−0.751	<.001	6	view →
LUSC	All	All	−0.715	<.001	6	view →
HNSC	Male	All	−0.537	<.001	6	view →
STAD	All	All	−0.639	.005	4	view →
READ	All	All	−1.350	.004	2	view →
CHOL	All	All	+0.752	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PDE1A–KIRC

Open the KIRC breakdown →