PDE1A

Across TCGA patient cohorts, PDE1A mutation is significantly associated with the RNA expression of many other genes, with 4,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE1A-associated genes across cancer lineages are SLC35B1, PHB, and CUEDC1. Each is linked with PDE1A in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE1A-to-partner and partner-to-PDE1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35B1 grouped by PDE1A-low versus PDE1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1A→partner) and Y-score (partner→PDE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC35B1 →	+0.397	+2.542	<.001	<.001	3	4
SKCM	PHB →	+0.299	+1.363	<.001	<.001	3	3
UCEC	CUEDC1 →	+0.609	+1.820	<.001	.001	3	3
SKCM	ZDHHC18 →	+0.258	+1.677	.001	.002	3	3
LUAD	BRIX1 →	+0.738	+3.193	<.001	.009	3	3
UCEC	MYO19 →	+0.404	+2.687	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,048 associations by consensus.

SLC35B1 by PDE1A expression — UCEC

Explore this box plot interactively →