PDE1A

Across TCGA patient cohorts, PDE1A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE1A-associated genes across cancer lineages are PRDX1, MEK1, and MYH11. Each is linked with PDE1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE1A-to-partner and partner-to-PDE1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by PDE1A-low versus PDE1A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1A→partner) and Y-score (partner→PDE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRDX1 →	+0.472	+3.009	<.001	.019	3	2
LUAD	MEK1 →	-0.261	-3.153	.016	.019	3	2
SKCM	MYH11 →	-0.614	-1.678	.012	.018	3	2
UCEC	p62 Lck ligand →	+0.226	+2.584	.049	.010	3	2
UCEC	STAT3_pY705 →	-0.322	-2.392	<.001	<.001	3	2
UCEC	ASNS →	+0.497	+1.584	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PRDX1 by PDE1A expression — LUSC

Explore this box plot interactively →