PDE1A

Across TCGA cell cohorts, PDE1A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,124 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PDE1A-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Cytoskeleton-dependent intracellular transport, and Vesicle coating. Each is linked with PDE1A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE1A-to-partner and partner-to-PDE1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by PDE1A-low versus PDE1A-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1A→partner) and Y-score (partner→PDE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.035	+0.188	<.001	.008	3	7
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.044	+1.217	.003	.005	3	6
PANCREAS	Vesicle coating →	+0.060	+0.104	.002	<.001	3	6
PANCREAS	COPII-coated vesicle budding →	+0.046	+0.082	.007	.005	3	6
BREAST	Transport along microtubule →	+0.044	+0.206	<.001	.006	3	6
BREAST	Axo-dendritic transport →	+0.070	+0.235	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,124 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by PDE1A expression — BLOOD_Leukemia

Explore this box plot interactively →