PDE1A

Across TCGA cell cohorts, PDE1A mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE1A-associated genes across cancer lineages are OR6T1, OR10G7, and LCE1F. Each is linked with PDE1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE1A-to-partner and partner-to-PDE1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by PDE1A-low versus PDE1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE1A→partner) and Y-score (partner→PDE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6T1 →	+0.052	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.151	+5.662	<.001	.002	3	1
SKIN	CACNA1B →	+0.185	+3.500	<.001	.008	2	2
SKIN	SFTA3 →	+0.181	+3.845	<.001	.003	3	1
SKIN	WNT8A →	+0.010	+3.345	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR6T1 by PDE1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →