PDE11A

Across TCGA pan-cancer cohorts, PDE11A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PDE11A data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PDE11A Mutation is associated with better overall survival. In most high-consensus cancer types, elevated PDE11A expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, HNSC, and LGG are the cancer types where PDE11A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.980	0.860	.008	34	view →
HNSC	OS	Median	II,III,IV	0.089	0.718	<.001	24	view →
LGG	OS	Median	All	0.171	0.812	<.001	18	view →
PAAD	OS	Median	All	0.060	0.641	<.001	12	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	11	view →
BLCA	OS	Median	III,IV	0.149	0.581	.020	6	view →
LIHC	OS	Median	All	0.444	0.781	.003	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
STAD	OS	Median	III,IV	1.000	0.615	.026	5	view →
READ	OS	Median	III,IV	0.328	0.751	.003	3	view →
LUSC	DFS	Median	All	0.666	0.377	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PDE11A–UCEC (OS)

Open the UCEC breakdown →