PDCL3P4

Across TCGA patient cohorts, PDCL3P4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL3P4-associated genes across cancer lineages are c-Met_pY1235, Bak, and mTOR_pS2448. Each is linked with PDCL3P4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL3P4-to-partner and partner-to-PDCL3P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by PDCL3P4-low versus PDCL3P4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL3P4→partner) and Y-score (partner→PDCL3P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.106	+2.817	.013	.036	3	1
UCEC	Bak →	+0.352	+3.000	.014	.037	2	1
UCEC	mTOR_pS2448 →	-0.249	-3.000	.003	.037	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.756	-2.986	.003	.037	1	1
UCEC	PKC-b-II_pS660 →	-0.388	-3.000	.015	.037	1	1
UCEC	STAT3_pY705 →	-0.485	-3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

c-Met_pY1235 by PDCL3P4 expression — UCEC

Explore this box plot interactively →