PDCL2

Across TCGA patient cohorts, PDCL2 mutation is significantly associated with the RNA expression of many other genes, with 1,985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL2-associated genes across cancer lineages are SEC61GP1, RNA5SP492, and RNU6-162P. Each is linked with PDCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL2-to-partner and partner-to-PDCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC61GP1 grouped by PDCL2-low versus PDCL2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL2→partner) and Y-score (partner→PDCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SEC61GP1 →	+0.454	+5.653	<.001	.003	3	2
UCEC	RNA5SP492 →	+0.197	+2.203	.001	.004	3	2
UCEC	RNU6-162P →	+0.083	+4.230	<.001	.004	3	2
UCEC	BTBD10 →	+0.473	+2.617	.002	.005	3	1
UCEC	ADM →	+1.002	+2.098	.001	.003	3	1
UCEC	LIN7C →	+0.541	+2.606	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,985 associations by consensus.

SEC61GP1 by PDCL2 expression — READ

Explore this box plot interactively →