PDCL2

Across TCGA patient cohorts, PDCL2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL2-associated genes across cancer lineages are eIF4E, Notch1, and Rad50. Each is linked with PDCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL2-to-partner and partner-to-PDCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PDCL2-low versus PDCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL2→partner) and Y-score (partner→PDCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.190	+2.906	.034	.001	3	2
UCEC	Notch1 →	+0.170	+2.183	.004	.033	3	1
UCEC	Rad50 →	-0.217	-2.222	.035	.011	3	1
UCEC	STAT3_pY705 →	-0.282	-1.700	.011	.044	3	1
UCEC	TIGAR →	+0.134	+2.248	.037	.006	3	1
UCEC	Tuberin →	+0.299	+1.700	.008	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by PDCL2 expression — UCEC

Explore this box plot interactively →