PDCL

Across TCGA patient cohorts, PDCL protein abundance is significantly associated with the RNA expression of many other genes, with 9,278 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDCL-associated genes across cancer lineages are PDZK1IP1, RBM18, and ERCC6L2. Each is linked with PDCL in more than 4 cancer types. Because this analysis shows association rather than direction, both PDCL-to-partner and partner-to-PDCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDCL versus PDZK1IP1 in OV, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL→partner) and Y-score (partner→PDCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDZK1IP1 →	-1.913	-0.348	<.001	<.001	3	5
OV	RBM18 →	+0.599	+0.409	.001	<.001	3	4
GBM	ERCC6L2 →	+0.441	+0.307	<.001	<.001	3	4
BRCA	PLIN5 →	-1.123	-0.223	.004	<.001	3	4
OV	ABHD17B →	+0.572	+0.435	.002	<.001	3	4
OV	RABGAP1 →	+0.539	+0.329	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,278 associations by consensus.

PDCL vs PDZK1IP1 — OV

Explore this scatter interactively →