PDCL

Across TCGA pan-cancer cohorts, PDCL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PDCL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDCL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDCL is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where PDCL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDCL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.896	<.001	11	view →
LIHC	Female	II,III,IV	+1.069	<.001	9	view →
THCA	All	All	−0.284	<.001	7	view →
LUAD	Female	III,IV	−0.760	<.001	6	view →
STAD	Male	II,III,IV	+0.678	<.001	6	view →
COAD	Male	All	+0.283	.010	6	view →
CHOL	Male	All	+1.981	<.001	5	view →
ESCA	All	All	+0.731	.008	3	view →
KIRC	All	All	+0.286	.002	3	view →
BLCA	Female	All	+0.373	.035	2	view →
BRCA	All	II,III,IV	+0.141	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PDCL–HNSC

Open the HNSC breakdown →