PDCL

Across TCGA patient cohorts, PDCL mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL-associated genes across cancer lineages are STAT3_pY705, 14-3-3_beta, and EGFR_pY1068. Each is linked with PDCL in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL-to-partner and partner-to-PDCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PDCL-low versus PDCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL→partner) and Y-score (partner→PDCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.477	-2.700	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.092	-3.143	.031	.018	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.222	.007	.011	3	1
UCEC	eIF4E →	+0.227	+2.906	.011	.001	3	1
UCEC	A-Raf_pS299 →	-0.167	-3.169	<.001	.018	3	1
UCEC	FoxM1 →	+0.239	+2.906	.029	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

STAT3_pY705 by PDCL expression — UCEC

Explore this box plot interactively →