PDCD7

Across TCGA patient cohorts, PDCD7 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD7-associated genes across cancer lineages are Notch1, PEA-15_pS116, and STAT3_pY705. Each is linked with PDCD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD7-to-partner and partner-to-PDCD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PDCD7-low versus PDCD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD7→partner) and Y-score (partner→PDCD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.194	+2.817	.011	.036	3	1
UCEC	PEA-15_pS116 →	+0.492	+3.169	.010	.020	3	1
UCEC	STAT3_pY705 →	-0.511	-2.999	<.001	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+1.149	+3.019	<.001	.019	3	1
UCEC	RAD51 →	+0.241	+3.169	.001	.020	1	1
UCEC	Annexin-1 →	+0.627	+3.169	.030	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by PDCD7 expression — UCEC

Explore this box plot interactively →