PDCD6IP

Across TCGA patient cohorts, PDCD6IP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD6IP-associated genes across cancer lineages are ATM, mTOR_pS2448, and Bak. Each is linked with PDCD6IP in more than 2 cancer types. Because this analysis shows association rather than direction, both PDCD6IP-to-partner and partner-to-PDCD6IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PDCD6IP-low versus PDCD6IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD6IP→partner) and Y-score (partner→PDCD6IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.602	-3.700	<.001	.001	3	3
UCEC	mTOR_pS2448 →	-0.143	-3.308	.008	.009	3	2
BLCA	Bak →	+0.294	+2.820	.001	.035	3	1
UCEC	14-3-3_beta →	-0.083	-2.432	.024	.018	3	1
UCEC	EGFR_pY1068 →	-0.272	-2.807	.003	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.091	-2.312	.047	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by PDCD6IP expression — UCEC

Explore this box plot interactively →